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Cyclic change of cytokines in a patient with cyclic thrombocytopenia
Author(s) -
Kimura Fumihiko,
Nakamura Yukistugu,
Sato Ken,
Wakimoto Naoki,
Kato Takashi,
Tahara Tomoyuki,
Yamada Muneo,
Nagata Naokazu,
Motoyoshi Kazuo
Publication year - 1996
Publication title -
british journal of haematology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.907
H-Index - 186
eISSN - 1365-2141
pISSN - 0007-1048
DOI - 10.1046/j.1365-2141.1996.d01-1783.x
Subject(s) - megakaryocytopoiesis , thrombopoietin , platelet , erythropoietin , hematopoietic growth factor , medicine , immunology , endocrinology , stem cell factor , platelet factor 4 , megakaryocyte , haematopoiesis , biology , stem cell , genetics
The serial change of various cytokines in the serum from a patient with cyclic thrombocytopenia is described. Interleukin 7, stem cell factor, and transforming growth factor β1 synchronized with the platelet count, and there was a significant positive correlation between the three cytokines and the platelet count. Levels of macrophage colony‐stimulating factor, thrombopoietin, platelet‐associated IgG and erythropoietin changed reciprocally with the platelet count, and there was a significant negative correlation between the platelet count and these cytokines except erythropoietin. No cyclic change was observed in IL‐3, IL‐6, IL‐11, granulocyte‐macrophage colony‐stimulating factor, or leukaemia inhibitory factor. These observations suggest that this disease involves two cyclic changes: megakaryocytopoiesis and platelet destruction, in both of which the cytokines play an important role.