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Coexistence of familial antiphospholipid syndrome and factor V Leiden: impact on thrombotic diathesis
Author(s) -
Brenner B.,
Vulfsons S. L.,
Lanir N.,
Nahir M.
Publication year - 1996
Publication title -
british journal of haematology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.907
H-Index - 186
eISSN - 1365-2141
pISSN - 0007-1048
DOI - 10.1046/j.1365-2141.1996.d01-1757.x
Subject(s) - factor v leiden , diathesis , medicine , antiphospholipid syndrome , hemorrhagic diathesis , factor v , thrombosis , immunology , venous thrombosis
Two young siblings who presented with an unusual recurrent severe thromboembolic phenomenon were found to have familial anti‐phospholipid syndrome and were heterozygous for the factor V R506Q mutation. The coexistence of hereditary and acquired APC‐resistance may explain the severity of thromboembolism.