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Duration of filgrastim mobilization and apheresis yield of CD34 + progenitor cells and lymphoid subsets in normal donors for allogeneic transplantation
Author(s) -
ANDERLINI PAOLO,
PRZEPIORKA DONNA,
HUH YANG,
LAUPPE JO,
MILLER PAULA,
SUNDBERG JANICE,
SEONG DAVID,
CHAMPLIN RICHARD,
KÖRBLING MARTIN
Publication year - 1996
Publication title -
british journal of haematology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.907
H-Index - 186
eISSN - 1365-2141
pISSN - 0007-1048
DOI - 10.1046/j.1365-2141.1996.d01-1747.x
Subject(s) - leukapheresis , filgrastim , apheresis , progenitor cell , transplantation , medicine , cd34 , immunology , granulocyte colony stimulating factor , stem cell , biology , chemotherapy , platelet , genetics
Seventy‐seven normal donors underwent leukapheresis for peripheral blood progenitor cell collection beginning on day 4 ( n = 45) or day 5 ( n = 32) of filgrastim mobilization (12 μg/kg/d). The two groups were comparable for age, weight, blood volumes processed during leukapheresis and target CD34 + cell dose to be collected. The day 5 schedule allowed a more consistent achievement of the target cell dose with one apheresis ( P = 0.005) and resulted in the initial collection of a significantly larger number of CD34 + cells ( P = 0.009). There was no statistically significant difference in the leukapheresis yield of lymphoid subsets and natural killer cells.