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CONTRIBUTION OF HAEMOLYSIS TO JAUNDICE IN SEPHARDIC JEWISH GLUCOSE‐6‐PHOSPHATE DEHYDROGENASE DEFICIENT NEONATES
Author(s) -
Kaplan Michael,
Vreman Hendrik J.,
Hammerman Cathy,
Leiter Chava,
Abramov Ayala,
Stevenson David K.
Publication year - 1996
Publication title -
british journal of haematology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.907
H-Index - 186
eISSN - 1365-2141
pISSN - 0007-1048
DOI - 10.1046/j.1365-2141.1996.d01-1745.x
Subject(s) - haemolysis , jaundice , judaism , glucosephosphate dehydrogenase deficiency , glucose 6 phosphate dehydrogenase , lactate dehydrogenase , glucose 6 phosphate dehydrogenase deficiency , medicine , immunology , dehydrogenase , biology , biochemistry , enzyme , history , archaeology
We determined the contribution of haemolysis to the development of hyperbilirubinaemia in glucose‐6‐phosphate dehydrogenase (G‐6‐PD) deficient neonates and G‐6‐PD normal controls. Blood carboxyhaemoglobin (COHb), sampled on the third day of life, was measured by gas chromatography, corrected for inhaled carbon monoxide (COHb C ), and expressed as a percentage of total haemoglobin concentration (Hb). Serum bilirubin was tested as clinically necessary. 37 non‐jaundiced (peak serum total bilirubin (PSTB) ≤255 μmol/l) and 20 jaundiced (PSTB ≥257 μmol/l) G‐6‐PD‐deficient neonates were compared to 31 non‐jaundiced and 24 jaundiced controls with comparable PSTB values, respectively. COHb C values for the entire G‐6‐PD deficient group were higher than in the controls (0.75 ± 0.17% v 0.62 ± 0.19%, P < 0.001). COHb C and PSTB values did not correlate in the G‐6‐PD‐deficient group ( r = 0.15, P > 0.05) but did in the controls ( r = 0.58, P < 0.001). COHb C values were increased to a similar extent in the G‐6‐PD‐deficient, non‐jaundiced (0.72 ± 0.16%), the G‐6‐PD‐deficient, jaundiced (0.80 ± 0.19%) and the control, jaundiced (0.75 ± 0.18%) subgroups, compared to the control, non‐jaundiced subgroup (0.53 ± 0.13%) ( P < 0.05). Although present in G‐6‐PD deficient neonates, increased haemolysis was not directly related to the PSTB.