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Tretinoin induces bone marrow collagenous fibrosis in acute promyelocytic leukaemia: new adverse, but reversible effect
Author(s) -
Hatake Kiyohiko,
Ohtsuki Tetsuya,
Uwai Masaya,
Takahashi Hironori,
Izumi Tohru,
Yoshida Minoru,
Kanai Nobuyuki,
Saito Ken,
Harigaya Kenichi,
Miura Yasusada
Publication year - 1996
Publication title -
british journal of haematology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.907
H-Index - 186
eISSN - 1365-2141
pISSN - 0007-1048
DOI - 10.1046/j.1365-2141.1996.d01-1708.x
Subject(s) - medicine , bone marrow , acute promyelocytic leukemia , stromal cell , tretinoin , chemotherapy , adverse effect , fibrosis , cancer research , pathology , in vitro , cell culture , retinoic acid , immunology , chemistry , biology , biochemistry , genetics
In 11/13 acute promyelocytic leukaemia (APL) cases treated with tretinoin (RA) we observed RA‐induced inaspirable collagenous fibrosis of the bone marrow. To study the mechanism of RA on collagen production, we cultured a human bone marrow derived stromal cell line and an osteoblastic cell line with RA in vitro . 10 −7 and 10 −6 M of RA stimulated collagen production. Clinical and experimental observation may be important to understand this adverse effect of RA as it is useful in cancer chemoprevention as well as treatment for APL. This adverse effect is spontaneously reversible after stopping RA or following chemotherapy.