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Isochromosome 12p in two cases of acute myeloid leukaemia without evidence of germ cell tumour
Author(s) -
HEIN Kristiina,
NAGESH RAO P.,
SLACK JAMES L.,
CRUZ JULIA,
BLOOMFIELD CLARA D.,
MRÓZEK KRZYSZTOF
Publication year - 1996
Publication title -
british journal of haematology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.907
H-Index - 186
eISSN - 1365-2141
pISSN - 0007-1048
DOI - 10.1046/j.1365-2141.1996.d01-1687.x
Subject(s) - isochromosome , medicine , myeloid , myeloid leukaemia , cancer research , karyotype , biology , genetics , gene , chromosome
An isochromosome 12p [i(12p)], typical of germ cell tumours (GCT), has, to date, been observed in 10 cases of acute myeloid leukaemia (AML) or myelodysplastic syndrome, nine of which had concurrent or preceding GCT. We report two i(12p)‐positive AML cases without clinical evidence of GCT. One patient with AML‐M1 had two i(12p) as the only cytogenetic anomalies. In the other case of AML‐M3 with t(15;17)(q22;q11‐12) at diagnosis, the i(12p) was clearly a secondary rearrangement since it first appeared at relapse and always accompanied the t(15;17). Our results suggest that i(12p) does not always indicate neoplastic disease of germ cell origin.