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Recombinant human G‐CSF‐mobilized peripheral blood stem cells for second allogeneic transplant after bone marrow graft rejection in children
Author(s) -
Zecca Marco,
Perotti Cesare,
Marradi Pierluigi,
Montagna Daniela,
Giorgiani Giovanna,
BALTER RITA,
Prete Luisella,
Locatell i Franco
Publication year - 1996
Publication title -
british journal of haematology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.907
H-Index - 186
eISSN - 1365-2141
pISSN - 0007-1048
DOI - 10.1046/j.1365-2141.1996.d01-1483.x
Subject(s) - medicine , granulocyte colony stimulating factor , human leukocyte antigen , bone marrow , stem cell , haematopoiesis , sibling , granulocyte , immunology , transplantation , graft versus host disease , surgery , antigen , chemotherapy , biology , psychology , developmental psychology , genetics
Two children affected by severe aplastic anaemia and sickle cell anaemia rejected the allogeneic bone marrow transplantation from an HLA‐matched unrelated volunteer and an HLA‐identical sibling, respectively. In both cases a second transplant using granulocyte‐colony stimulating factor (G‐CSF) mobilized peripheral blood stem cells (PBSC) was performed. Donors were the HLA‐haploidentical mother and the same HLA‐identical sibling who was employed for the first marrow allograft, respectively. Treatment with G‐CSF and PBSC collection were well tolerated. Both patients had engraftment of donor haemopoiesis and did not experience severe graft‐versus‐host disease. These cases confirm that PBSC transplant should be considered as a feasible treatment to reverse graft failure in paediatric patients.