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Heparin‐induced skin lesions
Author(s) -
Warkentin Theodore E.
Publication year - 1996
Publication title -
british journal of haematology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.907
H-Index - 186
eISSN - 1365-2141
pISSN - 0007-1048
DOI - 10.1046/j.1365-2141.1996.d01-1481.x
Subject(s) - heparin , heparin induced thrombocytopenia , platelet , medicine , complication , anticoagulant , platelet factor 4 , gastroenterology , immunology , surgery
Six patients who developed heparin‐induced skin lesions were tested for the presence of heparin‐dependent, platelet‐activating IgG irrespective of whether they developed thrombocytopenia. All six patients' sera contained potent heparin‐dependent, platelet‐activating IgG. However, only two of the six patients developed thrombocytopenia, and both of these patients developed thrombotic complications. One of the four patients who developed skin lesions without thrombocytopenia also developed a characteristic complication of heparin‐induced thrombocytopenia (adrenal haemorrhagic infarction). These observations indicate that formation of heparin‐dependent, platelet‐activating IgG is a consistent feature of patients who develop heparin‐induced skin lesions irrespective of whether thrombocytopenia occurs.