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Clinical significance of CD45RO expression on peripheral blood mononuclear cells in HTLV‐I‐infected individuals
Author(s) -
Suzuki Muneou,
Uno Hisamitsu,
Yamashita Kiyoshi,
Toyama Takanori,
Kubuki Youko,
Maeda Kouichi,
Matsuoka Hitoshi,
Ohtaki Sachiya,
Tsubouchi Hirohito
Publication year - 1996
Publication title -
british journal of haematology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.907
H-Index - 186
eISSN - 1365-2141
pISSN - 0007-1048
DOI - 10.1046/j.1365-2141.1996.d01-1474.x
Subject(s) - peripheral blood mononuclear cell , cd8 , immunophenotyping , cd3 , medicine , cd28 , immunology , il 2 receptor , phenotype , pathology , biology , antigen , t cell , immune system , in vitro , gene , biochemistry
The phenotype of peripheral blood mononuclear cells (PBMC) was examined in 13 healthy volunteers, 26 HTLV‐I carriers, and 58 ATL patients (22 smouldering, five chronic, 24 acute, and seven lymphoma type). The percentage of CD4 + , CD25 + , CD28 + and CD45RO + cells in the PBMC of the chronic and acute type patients was significantly higher than that of the volunteers, whereas the percentage of CD8 + and CD45RA + cells in these patients was significantly low. The histogram for CD45RO fluorescence intensity (FI) revealed two patterns: pattern A consisted of CD45RO + cells with high FI (CD45RO high ) and intermediate FI (CD45RO int ). Pattern B consisted exclusively of CD45RO high . Pattern A was evident in all volunteers. The percentage of subjects showing pattern B was increased in an order that reflected disease progression. In the patients with pattern A, the CD45RO int cells were CD4 + and CD8 − , and the FI of CD2, CD3, and Fas within the CD45RO int cells appeared to be lower than that within the CD45RO high cells. The acute type patients with pattern A had a significantly longer survival curve than that of these patients with pattern B. These results suggest that the presence of CD45RO int cells may be related to protection against disease progression in HTLV‐I‐infected individuals.