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2‐Chlorodeoxyadenosine in the treatment of hairy cell leukaemia: differences in response in patients with and without abdominal lymphadenopathy
Author(s) -
MERCIECA J.,
MATUTES E.,
EMMETT E.,
COLES H.,
CATOVSKY D.
Publication year - 1996
Publication title -
british journal of haematology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.907
H-Index - 186
eISSN - 1365-2141
pISSN - 0007-1048
DOI - 10.1046/j.1365-2141.1996.5041045.x
Subject(s) - deoxycoformycin , medicine , hairy cell leukemia , refractory (planetary science) , gastroenterology , hairy cell , cladribine , complete remission , surgery , chemotherapy , leukemia , physics , astrobiology , adenosine , adenosine deaminase
We treated 26 patients with hairy cell leukaemia (HCL) with 2‐chlorodeoxyadenosine, including nine with abdominal lymphadenopathy and of whom two had HCL‐variant; 18 were previously treated. The overall response in 23 evaluable HCL patients was 100% with 87% complete remission (CR). The CR rate was 57% in patients with abdominal lymphadenopathy. Neither of the patients with HCL‐variant achieved CR. Of four patients who had become refractory to 2′‐deoxycoformycin, two achieved CR and one partial remission (PR). The lower response in HCL with abdominal lymphadenopathy supports the view that this represents a more resistant form of the disease.