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Donor leucocyte transfusions for relapse in myelodysplastic syndrome after allogeneic bone marrow transplantation
Author(s) -
Okumura H.,
Takamatsu H.,
Yoshida T.
Publication year - 1996
Publication title -
british journal of haematology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.907
H-Index - 186
eISSN - 1365-2141
pISSN - 0007-1048
DOI - 10.1046/j.1365-2141.1996.4711019.x
Subject(s) - medicine , prednisolone , bone marrow , myelodysplastic syndromes , surgery , refractory (planetary science) , platelet , graft versus host disease , gastroenterology , transplantation , physics , astrobiology
A 31‐year‐old man with refractory anaemia of excess blasts, which had karyotypic abnormalities, received an allogeneic bone marrow transplant (BMT). At time of relapse, 3 months after BMT, he was treated with donor leucocyte transfusions (DLT). Grade III acute GVHD (graft‐versus‐host disease) occurred 35 d after DLT which was fully reversed with cyclosporin and prednisolone. His condition was complicated by a herpes zoster infection. 2 months after DLT, neutrophil and platelet count were increased and karyotypic abnormalities disappeared. This observation demonstrates that DLT is an effective treatment for relapse of myelodysplastic syndrome (MDS) after BMT.