Expression of multidrug resistance P‐glycoprotein in myeloid progenitor cells of different phenotype: comparison between normal bone marrow cells and leukaemia cells | Zendy

TAKESHITA AKIHIRO | Zendy; SHINJO KAORI | Zendy; OHNISHI KAZUNORI | Zendy; OHNO RYUZO | Zendy

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Expression of multidrug resistance P‐glycoprotein in myeloid progenitor cells of different phenotype: comparison between normal bone marrow cells and leukaemia cells

Author(s) -

TAKESHITA AKIHIRO,

SHINJO KAORI,

OHNISHI KAZUNORI,

OHNO RYUZO

Publication year - 1996

Publication title -

british journal of haematology

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 1.907

H-Index - 186

eISSN - 1365-2141

pISSN - 0007-1048

DOI - 10.1046/j.1365-2141.1996.459996.x

Subject(s) - cd33 , cd34 , bone marrow , myeloid , haematopoiesis , progenitor cell , stem cell , p glycoprotein , immunology , cancer research , flow cytometry , biology , immunophenotyping , microbiology and biotechnology , multiple drug resistance , drug resistance

We examined the multidrug resistant P‐glycoprotein (P‐gp) on normal bone marrow (BM) cells and acute myeloid leukaemia (AML) cells, using newly devised flow cytometric multi‐parameter analysis with CD33, CD34 and MRK16 monoclonal antibodies. In both normal BM cells and AML cells, CD34 + CD33 − cells expressed P‐gp strongly, CD34 + CD33 + cells moderately, and CD34 − CD33 + cells weakly. Acute promyelocytic leukaemia, mainly expressing CD34 − CD33 + but not CD34 + CD33 − at diagnosis, expressed less P‐gp. P‐gp expression of AML cells at diagnosis was increased as compared with normal cells of the same phenotype. P‐gp expression was more increased in relapsed cases, especially in immature subpopulations.

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