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Cytogenetic remission induced by interferon‐α in a myeloproliferative disorder with trisomy 8
Author(s) -
Petrini Mario,
Simi Paolo,
Saglio Giuseppe
Publication year - 1996
Publication title -
british journal of haematology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.907
H-Index - 186
eISSN - 1365-2141
pISSN - 0007-1048
DOI - 10.1046/j.1365-2141.1996.428966.x
Subject(s) - trisomy 8 , trisomy , clone (java method) , myeloproliferative disorders , bone marrow , hematology , spontaneous remission , aneuploidy , cytogenetics , pathology , g banding , karyotype , medicine , chromosome , biology , genetics , dna , alternative medicine , gene
We report a case of an unusual myeloproliferative disorder with trisomy of chromosome 8 characterized by peripheral blood thrombocythaemia and pronounced bone marrow myelodysplastic features. Treatment with interferon‐α at intermediate dosages, together with a complete bone marrow and peripheral blood haematology remission, was able to induce a cytogenetic remission, shown by the complete disappearance at the conventional cytogenetic analysis of trisomy 8 abnormality characterizing the neoplastic clone at diagnosis. However, trysomy 8 was still detectable by FISH in a small proportion of cells, showing that profound suppression of, but not complete eradication of, the neoplastic clone had occurred. The ability of interferon‐α to induce a major cytogenetic remission in a +8, Philadelphia‐chromosome negative, myeloproliferative disorder has not previously been documented and may provide further indications for the use of this drug in these disorders.