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Elevated plasma levels of vascular cell adhesion molecule‐1 (VCAM‐1) in diabetic patients with microalbuminuria: a marker of vascular dysfunction and progressive vascular disease
Author(s) -
Schmidt Ann Marie,
Crandall Jill,
Hori Osamu,
Cao Rong,
Lakatta Edward
Publication year - 1996
Publication title -
british journal of haematology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.907
H-Index - 186
eISSN - 1365-2141
pISSN - 0007-1048
DOI - 10.1046/j.1365-2141.1996.379915.x
Subject(s) - microalbuminuria , medicine , diabetes mellitus , endothelial dysfunction , vcam 1 , vascular disease , diabetic angiopathy , cell adhesion molecule , endocrinology , glycation , albuminuria , pathophysiology , immunology , icam 1
Advanced glycation endproducts (AGEs), which accumulate in diabetic vasculature, result in enhanced expression of endothelial cell‐associated vascular cell adhesion molecule‐1 (VCAM‐1) as well release of a soluble form of VCAM‐1 (sVCAM‐1) into culture supernatants. We hypothesized that sVCAM‐1 in diabetic plasma might reflect early vascular perturbation in diabetic vasculopathy. Diabetic patients with microalbuminuria, a group with a high incidence of vascular complications, had increased plasma levels of sVCAM‐1, ∼1.5‐fold greater than diabetic patients without microalbuminuria; P < 0.05. sVCAM‐1 may be an indicator of ongoing cellular dysfunction in diabetes, as well as a dynamic surrogate marker for the effectiveness of therapeutic interventions.