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Resolution of Budd‐Chiari syndrome following bone marrow transplantation for paroxysmal nocturnal haemoglobinuria
Author(s) -
Graham Michael L.,
Rosse Wendell F.,
Halperin Edward C.,
Miller Cindy R.,
Ware Russell E.
Publication year - 1996
Publication title -
british journal of haematology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.907
H-Index - 186
eISSN - 1365-2141
pISSN - 0007-1048
DOI - 10.1046/j.1365-2141.1996.365901.x
Subject(s) - medicine , budd–chiari syndrome , thrombosis , complication , surgery , transplantation , inferior vena cava
Thrombosis of the hepatic veins (Budd‐Chiari syndrome) is a life‐threatening thrombotic complication which can occur in patients with paroxysmal nocturnal haemoglobinuria (PNH). Despite aggressive medical and surgical therapy, mortality from Budd‐Chiari syndrome remains high. We report a boy with PNH who developed Budd‐Chiari syndrome and underwent syngeneic bone marrow transplantation (BMT). Now, 3 years following BMT, he has had dramatic clinical and radiographic evidence of resolution of the thrombosis. We suggest that BMT for PNH can successfully correct life‐threatening thrombosis in patients with PNH.