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Dyskeratosis congenita: an inherited bone marrow failure syndrome
Author(s) -
Dokal Inderjeet
Publication year - 1996
Publication title -
british journal of haematology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.907
H-Index - 186
eISSN - 1365-2141
pISSN - 0007-1048
DOI - 10.1046/j.1365-2141.1996.355881.x
Subject(s) - dyskeratosis congenita , medicine , medical school , citation , family medicine , hematology , pediatrics , dermatology , library science , medical education , computer science , genetics , biology , dna , telomere
Clinical features and natural history Cutaneous features are the most consistent feature of DC (Table I). Lacy reticulated skin pigmentation (Figs 1A and 1B) affecting the face, neck, chest and arms is a common finding. The degree of pigmentation increases with age and can involve the entire skin surface. Nail dystrophy (Fig 1D) is the next most common finding. It usually starts with longitudinal British Journal of Haematology, 1996, 92, 775–779