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A case of ovarian carcinoma with production of granulocyte colony‐stimulating factor
Author(s) -
Sudo Satoko,
Yamada Hideto,
Kikuchi Ken,
Sumie Akihiko,
Yamashita Yoichiro,
Tumura Norihiko,
Kawaguchi Isao,
Fujimoto Seiichiro,
Kato Atushi,
Yamaguchi Jun
Publication year - 1996
Publication title -
british journal of haematology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.907
H-Index - 186
eISSN - 1365-2141
pISSN - 0007-1048
DOI - 10.1046/j.1365-2141.1996.274811.x
Subject(s) - ovarian carcinoma , carboplatin , exploratory laparotomy , granulocyte colony stimulating factor , medicine , carcinoma , ovary , immunohistochemistry , chemotherapy , pathology , monoclonal antibody , granulocyte , ovarian cancer , oncology , cisplatin , antibody , cancer , immunology , surgery
A 60‐year‐old female with ovarian carcinoma showed marked leucocytosis. After exploratory laparotomy she had received carboplatin‐based chemotherapy, but she died of respiratory failure. In this case the immunohistochemical examination of the tumour cells showed partial‐positive staining for anti‐G‐CSF monoclonal antibody in addition to the elevation of the serum G‐CSF concentration. This case is the first report of an ovarian carcinoma producing G‐CSF.