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Successful treatment of HTLV‐1‐associated acute adult T‐cell leukaemia lymphoma by allogeneic bone marrow transplantation
Author(s) -
Borg Anton,
Liu Yin John A.,
JJohnson Peter R. E.,
Tosswill Jennifer,
Saunders Melanie,
Morris David
Publication year - 1996
Publication title -
british journal of haematology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.907
H-Index - 186
eISSN - 1365-2141
pISSN - 0007-1048
DOI - 10.1046/j.1365-2141.1996.02338.x
Subject(s) - medicine , etoposide , cyclophosphamide , lymphoma , chemotherapy , leukemia , bone marrow , transplantation , haematopoiesis , vincristine , disease , oncology , immunology , stem cell , biology , genetics
HTLV‐1‐associated acute adult T‐cell leukaemia‐lymphoma (ATL) is a highly aggressive malignant disorder with a median survival of 6 months or less. We describe an Afro‐Caribbean female with very poor prognosis ATL who underwent chemotherapy with a 4 d infusion schedule of cyclophosphamide, doxorubicin and etoposide, followed by successful allogeneic bone marrow transplantation (BMT) from her HTLV‐1‐negative histocompatibile sister. The patient remains in complete remission 23 months after BMT and has 100% donor haemopoiesis with no evidence of HTLV‐1 infection on PCR testing. We suggest that allo‐BMT can prolong disease‐free survival or may even be curative in HTLV patients.