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Effects of high‐dose granulocyte colony‐stimulating factor on neutrophil functions
Author(s) -
Yasui Kozo,
Tsuno Takahisa,
Miyabayashi Mari,
Yamazaki Munehiro,
Komiyama Atsushi
Publication year - 1996
Publication title -
british journal of haematology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.907
H-Index - 186
eISSN - 1365-2141
pISSN - 0007-1048
DOI - 10.1046/j.1365-2141.1996.00364.x
Subject(s) - granulocyte colony stimulating factor , granulocyte , neutrophile , immunology , medicine , absolute neutrophil count , toxicity , neutropenia , inflammation , chemotherapy
We evaluated the effects of high‐dose recombinant human granulocyte colony‐stimulating factor (rhG‐CSF) therapy on N‐formyl‐methionyl‐leucyl‐phenylalanine (FMLP)‐induced chemotaxis and superoxide (O − 2 ) production in neutrophils from four patients with aplastic anaemia. The FMLP‐induced chemotaxis and O − 2 production in the neutrophils of all four patients were normal before the rhG‐CSF treatment. After the administration of high‐dose rhG‐CSF, chemotaxis in agarose was decreased, adherence and O − 2 production were enhanced in all the patients. An excessive increase of neutrophils with augmented adhesiveness and oxygen radical production may be harmful. Care should be taken in regard to neutrophil toxicity when high‐dose G‐CSF is used clinically.