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Resolution of vulvitis circumscripta plasmacellularis with topical imiquimod: two case reports
Author(s) -
Ee H.L.,
Yosipovitch G.,
Chan R.,
Ong B.H.
Publication year - 2003
Publication title -
british journal of dermatology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.304
H-Index - 179
eISSN - 1365-2133
pISSN - 0007-0963
DOI - 10.1046/j.1365-2133.2003.05583.x
Subject(s) - imiquimod , vulvitis , medicine , dermatology , gynecology , vaginitis
Summary Vulvitis circumscripta plasmacellularis (VCP) is a rare but well‐described entity. It is notorious for its recalcitrant nature to various modalities of treatment. Intralesional interferon‐α showed some promise, with complete resolution, but is coupled with the side‐effect of myelosuppression. Topical imiquimod is a novel immune response modifier with the ability to induce the production of interferon‐α. In this paper, we report two cases of VCP whose lesions were resistant to antibiotics, topical and oral corticosteroids, but resolved after a treatment trial with imiquimod.