Panniculitis secondary to extravasation of clarithromycin in a patient with α1‐antitrypsin deficiency (phenotype PiZ)

Summary  α1‐Antitrypsin deficiency (AATD) is known to be associated with panniculitis. Although reports of this association are rare, the true incidence may be unappreciated because of underdiagnosis of AATD. We report a case of panniculitis occurring in a 34‐year‐old woman with severe AATD following the extravasation of clarithromycin infused intravenously for treatment of community‐acquired pneumonia. Resolution occurred with conservative management. The histopathology and management of this unusual condition are discussed, with a review of the literature.