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Idiopathic hypereosinophilic syndrome associated with cutaneous infarction and deep venous thrombosis
Author(s) -
Narayan S.,
Ezughah F.,
Standen G.R.,
Pawade J.,
Kennedy C.T.C.
Publication year - 2003
Publication title -
british journal of dermatology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.304
H-Index - 179
eISSN - 1365-2133
pISSN - 0007-0963
DOI - 10.1046/j.1365-2133.2003.05309.x
Subject(s) - medicine , hypereosinophilic syndrome , eosinophilia , etiology , venous thrombosis , thrombosis , infarction , dermatology , immunology , pathology , myocardial infarction
Summary We report a case of idiopathic hypereosinophilic syndrome (HES) presenting with cutaneous infarction and subsequent extensive deep vein thrombosis. The eosinophilia improved dramatically with systemic corticosteroid therapy. A variety of skin disorders have been associated with HES, although there are no previous reports of HES associated with cutaneous infarction. HES is a rare disorder characterized by a sustained overproduction of eosinophils and multisystem disease. The aetiology of the eosinophilia remains uncertain but clonal populations of abnormal T‐cells producing interleukin 5 may be implicated.