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Epstein–Barr virus‐associated T‐cell lymphoma: a case of eyelid swelling and intramuscular infiltration mimicking dermatomyositis
Author(s) -
Shirasaki F.,
Taniuchi K.,
Matsushita T.,
Hamaguhi Y.,
Takata M.,
Takehara K.
Publication year - 2002
Publication title -
british journal of dermatology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.304
H-Index - 179
eISSN - 1365-2133
pISSN - 0007-0963
DOI - 10.1046/j.1365-2133.2002.05037.x
Subject(s) - medicine , pathology , dermatomyositis , prednisolone , lymphoma , lung
Summary Association with Epstein–Barr virus (EBV) infection has been noted in various types of cutaneous lymphoproliferative disorders. We report a 57‐year‐old Japanese woman with T‐cell lymphoma mimicking dermatomyositis that was associated with chronic active EBV infection. She presented with low‐grade fever, bilateral erythematous swellings on the eyelids, and necrotic papules on the face. Serum creatine kinase levels were elevated and a diffuse reticular shadow was detected in both lung fields. The infiltrate of atypical lymphocytes found in skin and muscle, which contained EBV‐encoded small nuclear RNA‐1 and EBV, was also detected in the CD4+ peripheral blood cells. Treatment with prednisolone resolved her lesions with no relapse for 3 years, after which there was a recurrence in her left lung. Combination chemotherapy was not effective against the lung lesion and she died with multiple organ failure 2 months after the recurrence.