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Therapeutic apheresis exchange in two patients with prolidase deficiency
Author(s) -
Lupi A.,
Casado B.,
Soli M.,
Bertazzoni M.,
Annovazzi L.,
Viglio S.,
Cetta G.,
Iadarola P.
Publication year - 2002
Publication title -
british journal of dermatology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.304
H-Index - 179
eISSN - 1365-2133
pISSN - 0007-0963
DOI - 10.1046/j.1365-2133.2002.04998.x
Subject(s) - apheresis , medicine , concomitant , urinary system , gastroenterology , surgery , platelet
SummaryBackground Prolidase deficiency is a rare genetic disorder for which a cure has not yet been found. Objectives To assess the effectiveness of apheresis exchange as a new therapeutic approach. Methods Apheresis exchanges were repeated monthly for four consecutive months, in parallel, on two patients, replacing prolidase‐deficient red blood cells with normal filtered cells. Prolidase activity and urinary dipeptides were determined at regular intervals. Results The constant presence of active prolidase inside cells allowed a continuous, although partial, degradation of imidodipeptides, with a concomitant improvement of skin ulceration. Conclusions Apheresis exchange could be a reasonable way of obtaining a clinical improvement in these patients.