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Antidouble‐stranded DNA isotypes in lupus erythematosus patients with prevalent cutaneous presentation
Author(s) -
Parodi A.,
Drosera M.,
Barbieri L.,
Babbini G.,
Rebora A.
Publication year - 2002
Publication title -
british journal of dermatology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.304
H-Index - 179
eISSN - 1365-2133
pISSN - 0007-0963
DOI - 10.1046/j.1365-2133.2002.04939.x
Subject(s) - isotype , immunology , antibody , lupus erythematosus , medicine , systemic lupus erythematosus , systemic disease , anti dsdna antibodies , immunoglobulin a , immunoglobulin g , immunopathology , disease , pathology , monoclonal antibody
Summary Background Antidouble‐stranded DNA antibodies (anti‐dsDNA Ab), in particular of the IgG isotype, are usually considered a marker of systemic lupus erythematosus and often correlate with the disease activity. Objectives To determine IgG, IgA and IgM anti‐dsDNA Ab in a group of 330 patients with lupus erythematosus and prevalent cutaneous lesions. Methods The titre of anti‐dsDNA Ab was determined by enzyme‐linked immunosorbent assay, and disease activity was assessed by means of the systemic lupus activity measure. Results One hundred and six patients had anti‐dsDNA Ab. Thirty‐nine patients had antibodies of all three isotypes of immunoglobulins, 17 had IgG + IgM, five IgG + IgA, and two IgA + IgM. Forty‐three patients had a single isotype of anti‐dsDNA Ab. Patients with systemic disease and higher disease activity had antibodies of all three isotypes of immunoglobulins or of IgG isotype. Remarkably, anti‐dsDNA Ab of the IgA isotype, alone or associated with IgM, marked dermatological patients with low disease activity, but often with disquieting clinical and/or laboratory alterations. Conclusions These results indicate a correlation between disease activity and both frequency and isotype of anti‐dsDNA Ab.