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Extravascular necrotizing palisaded granulomas as the presenting skin sign of systemic lupus erythematosus
Author(s) -
Obermoser G.,
Zelger B.,
Zangerle R.,
Sepp N.
Publication year - 2002
Publication title -
british journal of dermatology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.304
H-Index - 179
eISSN - 1365-2133
pISSN - 0007-0963
DOI - 10.1046/j.1365-2133.2002.04790.x
Subject(s) - medicine , systemic disease , pathology , dermatology , systemic lupus , lupus erythematosus , disease , immunology , antibody
Summary We recently examined a patient who presented clinically with tender, erythematous papules associated with a febrile illness and polyarthralgias. Histopathological examination revealed extravascular palisaded neutrophilic granulomas, a skin reaction pattern originally described in Churg–Strauss disease but subsequently observed in a variety of other systemic disorders characterized by immune complex generation. A diagnosis of systemic lupus erythematosus (SLE) was established. To our knowledge, this is the first report of extravascular necrotizing palisaded granulomas as the presenting skin sign of SLE.