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Serum leptin concentration is increased in patients with Behçet's syndrome and is correlated with disease activity
Author(s) -
Evereklioglu C.,
Inalöz H.S.,
Kirtak N.,
Doganay S.,
Bülbül M.,
Otlu B.,
Özerol E.,
Er H.,
Özbek E.
Publication year - 2002
Publication title -
british journal of dermatology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.304
H-Index - 179
eISSN - 1365-2133
pISSN - 0007-0963
DOI - 10.1046/j.1365-2133.2002.04703.x
Subject(s) - leptin , medicine , erythrocyte sedimentation rate , endocrinology , body mass index , proinflammatory cytokine , inflammation , obesity
Summary Background Behçet's syndrome is a systemic, relapsing immuno‐inflammatory disease with a generalized vasculitis of the microvasculature endothelial dysfunction. Leptin, a recently discovered neuroendocrine hormone, is a metabolic peptide that appears to be involved. Serum proinflammatory cytokines upregulate leptin levels and leptin itself directly induces nitric oxide production from endothelial cells with its specific receptors. Objectives To detect changes of serum leptin concentrations in patients with Behçet's syndrome compared with age‐ and sex‐matched healthy volunteers by using enzyme‐linked immunosorbent assay. We also investigated whether disease activity or the duration of Behçet's syndrome correlates with leptin concentration. Methods Thirty‐five consecutive patients with Behçet's syndrome (41·2 ± 8·4 years, 16 male, 19 female) and 20 age‐ and sex‐matched healthy control subjects (40·4 ± 10·91 years, nine male, 11 female) were included in this study. The body mass index (BMI) [weight (kg) height −1 (m 2 )] was calculated for subjects at study enrolment. We measured serum leptin with a leptin enzyme immunoassay kit, and acute‐phase reactants, including erythrocyte sedimentation rate, α 1 ‐antitrypsin, α 2 ‐macroglobulin and neutrophil count. The Mann–Whitney U ‐test was used for statistical analysis and P < 0·05 was considered significant. Values were expressed as mean ± SD. Results The gender ratio, age and BMI were not substantially different among Behçet's patients and controls. The mean serum leptin concentrations in patients with Behçet's syndrome (16·8 ± 7·49 ng mL −1 ) were significantly ( P < 0·001) higher than in healthy control volunteers (7·5 ± 2·77 ng mL −1 ). Active Behçet's patients had significantly ( P = 0·001) higher leptin concentrations (20·5 ± 7·99 ng mL −1 ) when compared with patients in inactive periods (12·8 ± 4·43 ng mL −1 ). In addition, patients with longer disease duration (mean, 20·1 ± 5·15 years) had also significantly ( P = 0·013) higher leptin concentrations (20·2 ± 8·52 ng mL −1 ) than those with shorter disease duration (13·4 ± 4·52 ng mL −1 ) (mean, 7·4 ± 3·29 years). All acute‐phase reaction parameters were found to be significantly (for each, P < 0·01) increased in active disease. Conclusions Leptinmay have a role in modulating endothelial function and may be involved in mechanisms for vessel endothelium repair, during an exacerbation as well as in chronic disease.