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Local and systemic expression of basic fibroblast growth factor in a patient with familial glomangioma
Author(s) -
Kapur N.,
Lambiase P.,
Rakhit R.D.,
Pearce J.,
Orchard G.,
Calonje E.,
Dowd P.M.
Publication year - 2002
Publication title -
british journal of dermatology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.304
H-Index - 179
eISSN - 1365-2133
pISSN - 0007-0963
DOI - 10.1046/j.1365-2133.2002.04610.x
Subject(s) - angiogenesis , basic fibroblast growth factor , pathogenesis , fibroblast growth factor , immunohistochemistry , vascular endothelial growth factor , mutation , biology , pathology , fibroblast , growth factor , cancer research , medicine , gene , genetics , receptor , vegf receptors , cell culture
Summary Glomangiomas are rare cutaneous tumours composed of glomus cells, which are modified smooth muscle cells. The aetiology of this condition is thought to involve a mutation in a novel gene acting to regulate angiogenesis. We report a patient from a large family with three generations affected by familial multiple glomangiomas. We hypothesized that the growth factors basic fibroblast growth factor and vascular endothelial growth factor, which stimulate/regulate angiogenesis could be involved in the pathogenesis of these lesions. Therefore, using enzyme‐linked immunosorbent assays and immunohistochemistry, respectively, we measured systemic and tissue levels of these growth factors in a patient with familial glomangiomas. In addition, we investigated endothelial mitogenicity of the patient's serum as a functional assay of systemic growth factor activity.