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Treatment of disseminated granuloma annulare with a 5‐lipoxygenase inhibitor and vitamin E
Author(s) -
Smith K.J.,
Norwood C.,
Skelton H.
Publication year - 2002
Publication title -
british journal of dermatology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.304
H-Index - 179
eISSN - 1365-2133
pISSN - 0007-0963
DOI - 10.1046/j.1365-2133.2002.04590.x
Subject(s) - granuloma annulare , lipoxygenase , medicine , dermatology , arachidonate 5 lipoxygenase , vitamin , pharmacology , chemistry , enzyme , biochemistry , arachidonic acid
Summary Histologically, granuloma annulare (GA) is a common non‐infectious necrobiotic granulomatous reaction pattern that correlates with a number of different, but relatively specific clinical presentations. The cause or causes of GA are unknown: when localized, it is usually self‐limiting, but it may be persistent when disseminated. We present three women who had had disseminated GA for more than 1 year. One patient had previously been treated with isotretinoin with no response. All three patients were treated with vitamin E 400 IU daily and zileuton 2400 mg daily. All responded within 3 months with complete clinical clearing. The anti‐inflammatory and immune regulatory effects of vitamin E and zileuton may be an effective treatment in some patients with prolonged disseminated/generalized GA.