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Genotyping for HLA‐A, B and C alleles in Japanese patients with pemphigus: prevalence of Asian alleles of the HLA‐B15 family
Author(s) -
Miyagawa S.,
Niizeki H.,
Yamashina Y.,
Kaneshige T.
Publication year - 2002
Publication title -
british journal of dermatology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.304
H-Index - 179
eISSN - 1365-2133
pISSN - 0007-0963
DOI - 10.1046/j.1365-2133.2002.04564.x
Subject(s) - allele , human leukocyte antigen , genotyping , genetics , pemphigus vulgaris , linkage disequilibrium , biology , immunology , population , hla b antigens , haplotype , genotype , medicine , antigen , gene , environmental health
Summary Background There have been only limited reports on major histocompatibility complex class I antigens in pemphigus. Objectives To characterize HLA‐A, B and C class I alleles by genotyping in Japanese patients with pemphigus, and to analyse the possible association of class I alleles with disease susceptibility within a relatively homogeneous ethnic population. Methods Alleles of HLA‐A, B and C, and DRB1 and DQB1 loci were fully determined in 51 Japanese patients with pemphigus. Results Asian alleles of the HLA‐B15 family, including the allele B*1507, which was significantly increased in comparison with normal controls, were prevalent in patients with pemphigus vulgaris (PV). The prevalence of B*15 alleles in patients with PV was not due to linkage disequilibrium with HLA‐DR4 or DR14 alleles, which have been shown to confer strong susceptibility to PV across racial barriers. In contrast to the unique distribution of the HLA‐B alleles, HLA‐A and C alleles were unremarkable in patients with PV when compared with normal control subjects. Conclusions These results suggest that there may be differences in the ethnic concentrations of different HLA‐B alleles in patients with PV.