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Chronic urticaria associated with intra‐articular methylprednisolone
Author(s) -
Pollock B.,
Wilkinson S.M.,
Macdonald Hull S.P.
Publication year - 2001
Publication title -
british journal of dermatology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.304
H-Index - 179
eISSN - 1365-2133
pISSN - 0007-0963
DOI - 10.1046/j.1365-2133.2001.04238.x
Subject(s) - medicine , methylprednisolone , rash , dermatology , anesthesia , urticaria pigmentosa , corticosteroid , anaphylaxis , allergy , surgery , immunology
Reports of allergic reactions following treatment with systemic corticosteroids are rare, despite their widespread use. A 47‐year‐old man developed widespread urticaria, resistant to antihistamines, coinciding with injections of local anaesthetic and methylprednisolone for cervical spondylosis. He underwent immediate and delayed hypersensitivity tests. Intradermal tests showed immediate‐type sensitivity to methylprednisolone and hydrocortisone. Patch tests were positive to 21 of 26 corticosteroids tested. A diagnosis of both an immediate and a delayed‐type hypersensitivity to corticosteroids was made. With avoidance of all corticosteroids he has been free from urticarial rash for 9 months and has been able to stop all medication.