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The role of cutaneous dendritic cells in the immunopathogenesis of atopic dermatitis
Author(s) -
Banfield C.C.,
Callard R.E.,
Harper J.I.
Publication year - 2001
Publication title -
british journal of dermatology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.304
H-Index - 179
eISSN - 1365-2133
pISSN - 0007-0963
DOI - 10.1046/j.1365-2133.2001.04179.x
Subject(s) - atopic dermatitis , immunology , dendritic cell , immune system , medicine , cd8 , effector
We review the immunology of atopic dermatitis (AD) and focus attention on the role of cutaneous dendritic cells. AD is a complex immune‐mediated skin disorder characterized by the recruitment of both CD4+ and CD8+ T cells into the skin. T‐helper (Th) 2‐type cytokines are dominant in acute AD skin, while both Th1‐ and Th2‐type cytokines are present in chronic AD. Cutaneous dendritic cells, which are present in increased numbers within AD skin, are believed to play a key part in the activation of T cells in the skin. They may also help to determine the pattern of cytokines produced by activated effector T cells.