Premium
Rationale for use and clinical responsiveness of hexafluoro‐1,25‐dihydroxyvitamin D 3 for the treatment of plaque psoriasis: a pilot study
Author(s) -
Durakovic C.,
Malabanan A.,
Holick M.F.
Publication year - 2001
Publication title -
british journal of dermatology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.304
H-Index - 179
eISSN - 1365-2133
pISSN - 0007-0963
DOI - 10.1046/j.1365-2133.2001.04075.x
Subject(s) - psoriasis , medicine , placebo , psoriasis area and severity index , adverse effect , vitamin d and neurology , plaque psoriasis , severity of illness , calcitriol , dermatology , gastroenterology , surgery , pathology , alternative medicine
Background Vitamin D analogues are useful in topical therapy of psoriasis. Objectives To evaluate the effect of hexafluoro‐1,25‐dihydroxyvitamin D 3 (F 6 ‐1,25(OH) 2 D 3 ) in treatment of psoriasis. Methods Fifteen patients with plaque‐type psoriasis were enrolled in a single centre double‐blind, right/left comparison, placebo‐controlled study, and received 0·1 g of petrolatum containing 5 µg of F 6 ‐1,25(OH) 2 D 3 or 0·1 g of petrolatum (placebo) for 3 months. After completion of this double‐blind study, a subset of these patients ( n = 12) applied F 6 ‐1,25(OH) 2 D 3 ointment (50 µg g −1 of petrolatum) to all their lesions (total area, 100–5000 cm 2 , mean area: 3300 m 2 ) for 2 months as a single application at night. Results The mean severity score in the right/left‐sided controlled topical F 6 ‐1,25(OH) 2 D 3 (50 µg g −1 ) therapy group showed a decrease of 85%. In contrast, the mean severity score for the placebo‐treated areas showed a decrease of 45% ( P < 0·001). In the 12 patients who subsequently applied F 6 ‐1,25(OH) 2 D 3 (50 µg g −1 ) ointment to all of their lesions, 91·6% showed moderate to excellent improvement. The mean Psoriasis Area and Severity Index score decreased by 44·9% (from 33·6 ± 15 to 18·5 ± 13). No effect on calcium homeostasis was noted. Adverse events included mild irritation in two patients that resolved during therapy. Conclusions Topical F 6 ‐1,25(OH) 2 D 3 is a safe and effective once a day treatment for psoriasis.