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Severe digital necrosis in an elderly patient with heterozygous factor V Leiden mutation
Author(s) -
Patel G.K.,
Morris E.,
Rashid M.R.,
Anstey A.V.
Publication year - 2000
Publication title -
british journal of dermatology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.304
H-Index - 179
eISSN - 1365-2133
pISSN - 0007-0963
DOI - 10.1046/j.1365-2133.2000.03906.x
Subject(s) - purpura fulminans , medicine , factor v leiden , purpura (gastropod) , mutation , necrosis , dermatology , pediatrics , surgery , thrombosis , genetics , biology , ecology , venous thrombosis , gene
We report an 81‐year‐old female with a heterozygous factor V Leiden mutation who developed purpura fulminans. Digital necrosis, a characteristic clinical feature of purpura fulminans was prominent. Purpura fulminans is more common in children and adult cases are rare. Of eight reported cases of purpura fulminans resulting from a heterozygous factor V Leiden mutation recorded in the literature, only two were in adults: 40 and 42 years of age, respectively. This is the first report of this condition arising in a patient in her eighties.