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Calciphylaxis in a patient without renal failure or elevated parathyroid hormone: possible aetiological role of chemotherapy
Author(s) -
Goyal S.,
Huhn K.M.,
Provost T.T.
Publication year - 2000
Publication title -
british journal of dermatology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.304
H-Index - 179
eISSN - 1365-2133
pISSN - 0007-0963
DOI - 10.1046/j.1365-2133.2000.03853.x
Subject(s) - calciphylaxis , medicine , etiology , parathyroid hormone , dialysis , chemotherapy , hyperparathyroidism , hemodialysis , transplantation , secondary hyperparathyroidism , disease , surgery , calcium
Calciphylaxis is a rare, often fatal disease characterized clinically by progressive cutaneous necrosis and ulceration, and histologically by vascular calcification and thrombosis. It has been described in association with end‐stage renal disease, after initiation of dialysis, following renal transplantation, and in patients with hyperparathyroidism. We present the first case of calciphylaxis occurring in a patient with both normal renal function and parathyroid hormone level and discuss the possible aetiological role of chemotherapy‐induced functional protein C and protein S deficiency.