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Leucoderma associated with flares of erythrodermic cutaneous T‐cell lymphomas: four cases
Author(s) -
Bouloc A.,
Grange F.,
DelfauLarue M.H.,
Dieng M.T.,
Tortel M.C.,
Avril M.F.,
Revuz J.,
Bagot M.,
Wechsler J.
Publication year - 2000
Publication title -
british journal of dermatology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.304
H-Index - 179
eISSN - 1365-2133
pISSN - 0007-0963
DOI - 10.1046/j.1365-2133.2000.03851.x
Subject(s) - mycosis fungoides , hypopigmentation , erythroderma , dermatology , medicine , vitiligo , biopsy , cutaneous t cell lymphoma , lymphoma , skin biopsy , pathology
We describe four patients with erythrodermic cutaneous T‐cell lymphomas (two with erythrodermic mycosis fungoides, and two with Sézary syndrome) who presented with extensive hypopigmented lesions that occurred during flares of their cutaneous disease. These cases must be distinguished from previously described hypopigmented mycosis fungoides where hypopigmented lesions were the sole manifestation of the lymphoma. In two cases a biopsy was performed on hypopigmented skin, showing an infiltrate of atypical lymphocytes with epidermotropism and absence of melanocytes, as in vitiligo. It is suggested that the hypopigmentation could be due to the cytotoxicity of tumour or reactional lymphocytes directed against melanocytes.