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Immunohistochemical expression of bone morphogenetic protein‐2 in pilomatricoma
Author(s) -
Kurokawa I.,
Kusumoto K.,
Bessho K.,
Okubo Y.,
Senzaki H.,
Tsubura A.
Publication year - 2000
Publication title -
british journal of dermatology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.304
H-Index - 179
eISSN - 1365-2133
pISSN - 0007-0963
DOI - 10.1046/j.1365-2133.2000.03771.x
Subject(s) - pilomatricoma , ossification , bone morphogenetic protein , basophilic , immunohistochemistry , calcification , pilomatrixoma , bone morphogenetic protein 2 , pathology , ectopic calcification , bone formation , medicine , inner root sheath , anatomy , biology , in vitro , outer root sheath , biochemistry , gene
Background The mechanism of occurrence of calcification and ossification in pilomatricoma remains unclear. Objectives To elucidate the pathogenesis of calcification and ossification in pilomatricoma we examined the role of bone morphogenetic protein (BMP)‐2, which plays important parts in inducing ectopic bone formation both in vivo and in vitro . Methods Twenty cases of pilomatricoma were studied immunohistochemically using anti‐BMP‐2 monoclonal antibody. Results In normal skin, including hair follicles, there was no BMP‐2 expression. In all pilomatricomas, BMP‐2 was found exclusively in the cytoplasm of shadow cells but not in basophilic cells. In two cases of bone formation seen in pilomatricoma, osteoblasts in the periosteal area showed a strong positive reaction, while bone trabeculum (bone matrix) showed no reaction. Conclusions Our findings indicate that shadow cells positive for BMP‐2 may play an important part in generating bone formation in pilomatricoma.