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Eosinophilic spongiosis in association with bullous pemphigoid and chronic lymphocytic leukaemia
Author(s) -
Ameen M.,
Pembroke A.C.,
Black M.M.,
RussellJones R.
Publication year - 2000
Publication title -
british journal of dermatology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.304
H-Index - 179
eISSN - 1365-2133
pISSN - 0007-0963
DOI - 10.1046/j.1365-2133.2000.03674.x
Subject(s) - spongiosis , medicine , bullous pemphigoid , dermatology , chronic lymphocytic leukemia , pathology , pemphigoid , immunofluorescence , immunology , leukemia , antibody
We report the onset of an unusual blistering eruption following a diagnosis of B‐cell chronic lymphocytic leukaemia (CLL). The histology consistently showed eosinophilic spongiosis, but the diagnosis of bullous pemphigoid was only confirmed after 13 years by repeated immunofluorescence studies. The occurrence of subepidermal blistering diseases in association with B‐cell lymphoproliferative disorders is rare; a recent study showed that the majority of these cases are epidermolysis bullosa acquisita, confirmed by immunological studies. Only two cases of immunofluorescence‐proven bullous pemphigoid in association with CLL have been previously reported.