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Increased serum levels of soluble vascular cell adhesion molecule‐1 and soluble E‐selectin in patients with polymyositis/dermatomyositis
Author(s) -
Kubo M.,
Ihn H.,
Yamane K.,
Yazawa N.,
Kikuchi K.,
Soma Y.,
Tamaki K.
Publication year - 2000
Publication title -
british journal of dermatology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.304
H-Index - 179
eISSN - 1365-2133
pISSN - 0007-0963
DOI - 10.1046/j.1365-2133.2000.03668.x
Subject(s) - dermatomyositis , polymyositis , medicine , endocrinology , cell adhesion molecule , creatine kinase , erythrocyte sedimentation rate , immunology
Background Elevated levels of soluble vascular cell adhesion molecule‐1 (sVCAM‐1) and soluble E‐selectin (sE‐selectin) have previously been reported in patients with various inflammatory diseases, but not in patients with polymyositis/dermatomyositis (PM/DM). Objectives To determine serum levels and significance of sVCAM‐1 and sE‐selectin in patients with PM/DM. Patients and methods Serum samples from 36 PM/DM patients, 30 patients with systemic sclerosis and 25 healthy control subjects were examined using specific enzyme‐linked immunosorbent assay systems. Results The serum levels of sVCAM‐1 in the PM/DM patients were significantly higher than those in the healthy controls. The elevated serum sVCAM‐1 levels were correlated with the values of elevated erythrocyte sedimentation rate and elevated serum hyaluronate levels in the PM/DM patients. The serum sE‐selectin levels in the PM/DM patients were also significantly higher than those in the healthy controls. The elevated serum sE‐selectin levels were correlated with the incidence of elevated creatine kinase activities. The concentrations of serum sE‐selectin were correlated with the serum tissue inhibitor of metalloproteinase‐1 concentrations in the PM/DM patients ( r = 0·53). Conclusions These results suggest that serum sVCAM‐1 and sE‐selectin levels might be useful for detecting disease activity in patients with PM/DM.