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Malignant melanoma and lymphoproliferative malignancy: is there a shared aetiology?
Author(s) -
Mckenna D.B.,
Doherty V.R.,
Mclaren K.M.,
Hunter J.A.A.
Publication year - 2000
Publication title -
british journal of dermatology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.304
H-Index - 179
eISSN - 1365-2133
pISSN - 0007-0963
DOI - 10.1046/j.1365-2133.2000.03610.x
Subject(s) - immunosuppression , medicine , melanoma , malignancy , lymphoma , lymphoproliferative disorders , etiology , radiation therapy , chemotherapy , lymphatic system , cancer , dermatology , immunology , oncology , pathology , cancer research
We report seven patients who developed malignant melanoma either coincident with or before the diagnosis of non‐Hodgkin’s lymphoma or chronic lymphatic leukaemia. One patient died secondary to leukaemia, and chemotherapy‐induced immunosuppression may have contributed to the development of metastatic melanoma in another patient. Immunosuppression, exposure to ultraviolet radiation and genetic factors may result in a host environment that is conducive to the development of both tumours in these patients.