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Pseudoscleroderma associated with lung cancer: correlation of collagen type I and connective tissue growth factor gene expression
Author(s) -
Querfeld C.,
Sollberg S.,
Huerkamp C.,
Eckes B.,
Krieg T.
Publication year - 2000
Publication title -
british journal of dermatology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.304
H-Index - 179
eISSN - 1365-2133
pISSN - 0007-0963
DOI - 10.1046/j.1365-2133.2000.03579.x
Subject(s) - ctgf , connective tissue , dermis , transforming growth factor , pathology , growth factor , connective tissue disease , in situ hybridization , gene expression , lung cancer , biology , cancer research , medicine , gene , endocrinology , disease , autoimmune disease , biochemistry , receptor
Pseudoscleroderma as a paraneoplastic syndrome is a rare disease. We report here a patient with lung cancer (undifferentiated squamous cell carcinoma), who developed acrosclerosis. Using in situ hybridization, marked expression of α1(I)‐collagen and connective tissue growth factor (CTGF) mRNA was found in fibroblasts scattered throughout the dermis. However, transforming growth factor (TGF)‐β1 expression was not detected. The pattern of CTGF gene expression and collagen synthesis was similar to that in systemic scleroderma. The absence of TGF‐β1 mRNA could indicate that tumour‐derived factors induce the expression of CTGF.