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Photosensitive mycosis fungoides or actinic reticuloid?
Author(s) -
De Silva B.D.,
Mclaren K.,
Kavanagh G.M.
Publication year - 2000
Publication title -
british journal of dermatology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.304
H-Index - 179
eISSN - 1365-2133
pISSN - 0007-0963
DOI - 10.1046/j.1365-2133.2000.03555.x
Subject(s) - mycosis fungoides , dermatology , medicine , photodermatosis , peripheral t cell lymphoma , pathology , gene , lymphoma , biology , immunology , t cell , genetics , immune system , xeroderma pigmentosum , dna repair
We report two patients who satisfied the diagnostic criteria for actinic reticuloid (AR) on initial presentation, in whom genotypic analysis of early skin biopsies failed to show T‐cell gene receptor rearrangements. Both patients progressed to widespread skin involvement associated with histopathological and genotypic features of mycosis fungoides (MF). Arguably, these patients may have had photosensitive MF from the outset, but their clinical features, phototesting, and subsequent demonstration of a T‐cell gene receptor rearrangement in the skin could also suggest progression of AR to MF.