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Clinicopathological features of CD56+ nasal‐type T/natural killer cell lymphomas with lobular panniculitis
Author(s) -
Chang SE.,
Huh J.,
Choi JH.,
Sung KJ.,
Moon KC.,
Koh JK.
Publication year - 2000
Publication title -
british journal of dermatology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.304
H-Index - 179
eISSN - 1365-2133
pISSN - 0007-0963
DOI - 10.1046/j.1365-2133.2000.03472.x
Subject(s) - pathology , medicine , immunophenotyping , lymphoma , cd30 , panniculitis , cutaneous lymphoma , differential diagnosis , histology , mycosis fungoides , immunology , antigen
Nasal‐type T/natural killer cell lymphoma (TNKCL) shows frequent extranodal involvement including the skin, and is associated with a poor prognosis. We have studied six patients with nasal‐type TNKCL presenting with inflammatory subcutaneous nodular lesions with a subcutaneous lymphoid infiltrate. Clinical information was obtained from the medical records of the patients and at follow‐up. All cases showed features of angiocentric lymphoma on histology, although there was diffuse cellular infiltration rather than an angiocentric pattern in the subcutis. All six patients were similar in immunophenotype: positive for CD56 and either cytoplasmic CD3 or CD45RO, but negative for B‐cell markers and CD30. In situ hybridization using an anti‐sense Epstein–Barr virus early regions probe showed a positive reaction in all cases. All patients either died with progressive disease or showed no response to combined chemotherapy. The diagnosis of nasal‐type TNKCL, which has a fatal outcome, is facilitated by detection of CD56‐positive tumour cells. In evaluating lobular panniculitis including apparently benign inflammatory subcutaneous nodules, nasal‐type TNKCL should be considered in the differential diagnosis, especially in Asian countries.