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Barrier recovery rate varies time‐dependently in human skin
Author(s) -
Denda M.,
Tsuchiya T.
Publication year - 2000
Publication title -
british journal of dermatology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.304
H-Index - 179
eISSN - 1365-2133
pISSN - 0007-0963
DOI - 10.1046/j.1365-2133.2000.03466.x
Subject(s) - transepidermal water loss , skin barrier , human skin , skin temperature , forearm , medicine , basal (medicine) , barrier function , chemistry , endocrinology , surgery , dermatology , biology , pathology , stratum corneum , insulin , microbiology and biotechnology , genetics
The recovery in cutaneous barrier functions, assessed in terms of transepidermal water loss, 1 h after tape stripping of volar forearm skin in human volunteers, was investigated at different times over the 24 h day. The barrier recovery rate was significantly lower between 20:00 h and 23:00 h than that at other time points. The skin surface temperature and the basal transepidermal water loss reached their highest values at about 03:00 h (33·6 °C and 0·30 mg cm −2 h −1 ), while the cortisol level in the saliva was highest at 09:00 h (7·8 pmol mL −1 ). These results suggest significant time‐dependent variation in cutaneous barrier repair independent of changes in skin temperature and cortisol level.