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SHORT COMMUNICATION Photodynamic therapy with delta‐aminolaevulinic acid for nodular basal cell carcinomas using a prior debulking technique
Author(s) -
Thissen M.R.T.M.,
Schroeter C.A.,
Neumann H.A.M.
Publication year - 2000
Publication title -
british journal of dermatology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.304
H-Index - 179
eISSN - 1365-2133
pISSN - 0007-0963
DOI - 10.1046/j.1365-2133.2000.03404.x
Subject(s) - debulking , medicine , photodynamic therapy , basal cell carcinoma , basal cell , dermatology , surgery , pathology , cancer , chemistry , organic chemistry , ovarian cancer
The incidence of basal cell carcinomas (BCCs) is still increasing, and there is a demand for an easy, effective and selective non‐invasive treatment such as topical photodynamic therapy (PDT). Twenty‐three patients with 24 nodular BCCs were treated once with delta‐aminolaevulinic acid (δ‐ALA) PDT (100 mW cm −2 , 120 J/cm 2 ) 3 weeks after prior debulking of the BCCs. Three months after PDT, all lesions were surgically excised and histopathologically evaluated for residual tumour. Twenty‐two (92%) of the 24 nodular BCCs showed a complete response on clinical and histopathological examination. PDT for superficially abraded nodular BCCs with topically applied δ‐ALA and the VersaLight ® as light source is an easy, effective and safe therapy, with excellent cosmetic results and no serious side‐effects, in cases where non‐surgical treatment of BCCs is indicated.