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Squamous cell carcinoma arising in Hailey–Hailey disease of the vulva
Author(s) -
Cockayne S.E.,
Rassl D.M.,
Thomas S.E.
Publication year - 2000
Publication title -
british journal of dermatology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.304
H-Index - 179
eISSN - 1365-2133
pISSN - 0007-0963
DOI - 10.1046/j.1365-2133.2000.03374.x
Subject(s) - vulva , hailey–hailey disease , medicine , dermatology , vulvectomy , biopsy , basal cell , pathology , carcinoma , disease , vulvar intraepithelial neoplasia , vulvar cancer
A 61–year‐old woman, who was known to have Hailey–Hailey disease, presented with increasing vulval soreness. Biopsy showed vulval intraepithelial neoplasia (VIN) 3 and subsequent histology from a vulvectomy specimen showed extensive VIN with early invasive squamous cell carcinoma. This may be another example of chronic inflammation of the vulval area leading to the development of squamous cell carcinoma. However, in this case, chronic human papillomavirus may also have played a part, leading to VIN and reactivation of the Hailey–Hailey disease. We can find no previous reports of squamous cell carcinoma developing in the setting of Hailey–Hailey disease.