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Macroscopic and microscopic mucinosis in chronicsclerodermoid graft‐versus‐host disease
Author(s) -
Ameen M.,
RussellJones R.
Publication year - 2000
Publication title -
british journal of dermatology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.304
H-Index - 179
eISSN - 1365-2133
pISSN - 0007-0963
DOI - 10.1046/j.1365-2133.2000.03371.x
Subject(s) - mucinosis , pathology , dermis , dermatomyositis , reticular connective tissue , connective tissue , mucin , medicine , connective tissue disease , reticular dermis , scars , ground substance , papillary dermis , lupus erythematosus , systemic disease , dermatology , disease , autoimmune disease , immunology , antibody
Secondary cutaneous mucinosis is a well‐recognized feature of connective tissue diseases such as lupus erythematosus and dermatomyositis. We report the first three cases of dermal mucinosis in association with severe chronic cutaneous graft‐versus‐host disease of the sclerodermoid variety. One patient had clinical changes due to abundant mucin accumulation within the papillary dermis (mucinoma). In the other two patients histological examination revealed extensive deposits of mucin predominantly within the reticular dermis. The microscopic appearances were striking, with numerous vacuolated spaces interspersed between collagen bundles. We speculate that this appearance is the result of ground substance becoming trapped within grossly sclerodermoid connective tissue.