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Molluscum contagiosum effectively treated with a topical acidified nitrite, nitric oxide liberating cream
Author(s) -
Ormerod A.D.,
White M.I.,
Shah S.A.A.,
Benjamin N.
Publication year - 1999
Publication title -
british journal of dermatology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.304
H-Index - 179
eISSN - 1365-2133
pISSN - 0007-0963
DOI - 10.1046/j.1365-2133.1999.03204.x
Subject(s) - sodium nitrite , molluscum contagiosum , salicylic acid , medicine , nitrite , dermatology , nitric oxide , cure rate , irritation , surgery , chemistry , immunology , food science , biochemistry , nitrate , organic chemistry
A double‐blind, group‐sequential clinical trial of acidified nitrite was performed to demonstrate the efficacy of this nitric oxide donor in treating molluscum contagiosum. Subjects received either 5% sodium nitrite co‐applied with 5% salicylic acid under occlusion, or identical cream with 5% salicylic acid, omitting sodium nitrite. Active and control treatment groups were well matched for the number and duration of lesions and made a similar number of applications. We found a 75% cure rate in the active treatment group and 21% cure with control treatment ( P = 0·01). The mean time to cure was 1·83 months. Staining of the skin and irritation were frequent side‐effects but did not prevent successful treatment.