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Persistent ulcerated necrobiosis lipoidica responding to treatment with cyclosporin
Author(s) -
Darvay,
Acland,
RussellJones
Publication year - 1999
Publication title -
british journal of dermatology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.304
H-Index - 179
eISSN - 1365-2133
pISSN - 0007-0963
DOI - 10.1046/j.1365-2133.1999.03119.x
Subject(s) - necrobiosis lipoidica , medicine , context (archaeology) , dermatology , surgery , diabetes mellitus , paleontology , biology , endocrinology
We report two patients with severe ulcerated necrobiosis lipoidica (NL) who responded to cyclosporin. One patient had suffered persistent ulceration for a period of 7 years and the other had NL of recent onset. In both cases, ulceration healed completely after 4 months of therapy, and both patients have remained free of ulceration since discontinuing therapy. The possible mode of action of cyclosporin in the context of this debilitating disease is discussed.