Premium
Overexpression of p2l Waf1/Cip1 immunohistochemical staining in Bowen's disease, but not in disseminated superficial porokeratosis
Author(s) -
Tamihiro Kawakami,
Ryuzo Saito,
Kei Takahashi
Publication year - 1999
Publication title -
british journal of dermatology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.304
H-Index - 179
eISSN - 1365-2133
pISSN - 0007-0963
DOI - 10.1046/j.1365-2133.1999.03102.x
Subject(s) - porokeratosis , bowen's disease , immunohistochemistry , pathology , pathogenesis , biology , dyskeratosis , carcinogenesis , immunostaining , hyperkeratosis , cancer research , medicine , cancer , basal cell , genetics
Disseminated superficial porokeratosis (DSP) consists of multiple small lesions of porokeratosis. Although the pathogenesis of DSP remains unclear, localized cloning of abnormal epidermis has been hypothesized. Malignant cutaneous neoplasms, especially Bowen's disease, have been frequently reported in DSP. Immunopositive p53 has been demonstrated in a variety of human malignant tumours, and its role in oncogenesis and tumour progression is thought to be important. p21 Waf1/Cip1 is thought to mediate the signal of p53 induced by DNA damaging agents to arrest the cell cycle. To clarify the role of p53 and p21 Waf1/Cip1 in Bowen's disease and DSP, we analysed 12 cases of Bowen's disease and eight cases of DSP by immunohistochemistry. In five of the 12 Bowen's disease patients and two of the eight DSP patients, positive p53 staining was detected. In contrast, whereas p21 Waf1/Cip1 overexpression was detected in all Bowen's disease patients, it was not seen in DSP. The present data suggest that p53 immunostaining provides relevant information concerning the pathogenesis of Bowen's disease and DSP. Furthermore, high p21 Waf1/Cip1 expression appears to be a useful indicator of tumour activity in Bowen's disease.